The glowing panoply of fluorogen-based markers for advanced bioimaging.
In Optogenetics – a comprehensive manual for light-driven actuators and light-emitting sensors in cell biology, Photochemical and Photobiological Sciences Series (S. Vriz & T. Ozawa Eds), The Royal Society of Chemistry (just accepted).
A. Gautier


Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations.
Nature Communications 8, 969 (2017).
J. Querard, R. Zhang, Z. Kelemen, M.-A. Plamont, X. Xie, R. Chouket, I. Roemgens, Y. Koperina, S. Albright, E. Ipendey, M. Volovitch, H. L. Sladitschek, P. Neveu, L. Gissot, A. Gautier, J.-D. Faure, V. Croquette, T. Le Saux & L. Jullien

Chromophore renewal and fluorogen-binding tags: a match made to last.
Scientific Reports 7, 12316 (2017)
F. M. Pimenta, G. Chiappetta, T. Le Saux, J. Vihn, L. Jullien & A. Gautier

Fluorogenic labeling strategies for biological imaging.
International Journal of Molecular Sciences 18, 1473 (2017).
C. Li, A. G. Tebo & A. Gautier

Hybrid fluorescent probes for imaging cellular proteins on demand.
Médecine/Sciences 33 (6-7), 576-578 (2017).
L. Jullien & A. Gautier

Membrane-impermeant fluorogenic chromophores.
Patent Application number : EP17305591.4
A. Gautier, L. Jullien, C. Li, F. Perez

Dynamic multi-color protein labeling in living cells.
Chemical Science 8, 5598–5605 (2017) 
C. Li, M.-A. Plamont, H. Sladitschek, V. Rodrigues, I. Aujard, P. Neveu, T. Le Saux, L. Jullien & A. Gautier

PSL Chemical Biology Symposium First 2016 Edition: When Chemistry and Biology share the language of discovery.
ChemBioChem 18, 883-887 (2017).
A. Gautier & R. Rodriguez


Design and characterization of red fluorogenic push-pull chromophores holding great potential for biosensing and imaging.
Organic and Biomolecular Chemistry 14, 9253-9261 (2016).
C. Li, M.-A. Plamont, I. Aujard, T. Le Saux, L. Jullien & A. Gautier

Kinetics of reactive modules adds discriminative dimensions for selective cell imaging.
ChemPhysChem 17, 1396-1413 (2016).
J. Quérard, T. Le Saux, A. Gautier, D. Alcor, V. Croquette, C. Gosse, A. Lemarchand & L. Jullien

A small fluorescence-activating and absorption-shifting tag for tunable protein imaging in vivo.
Proceedings of the National Academy of Sciences (PNAS) 113 (3), 497-502 (2016).   
M.-A. Plamont, E. Billon-Denis, S. Maurin, C. Gauron, F. M. Pimenta, C. G. Specht, J. Shi, J. Querard, B. Pan, J. Rossignol, K. Moncoq, N. Morellet, M. Volovitch, E. Lescop, Y. Chen, A. Triller, S. Vriz, T. Le Saux, L. Jullien & A. Gautier
Highlighted in ‘This week in PNAS’ in PNAS 113 (3), 465-467 (2016).


Fluorogen-based reporters for fluorescence imaging: a review.
Methods and Applications in Fluorescence 3, 042007 (2015).
L. Jullien & A. Gautier

Light-activated proteolysis for the spatiotemporal control of proteins.
ACS Chemical Biology 10, 1643-1647 (2015). 
Q. Delacour, C. Li, M.-A. Plamont, E. Billon-Denis, I. Aujard, T. Le Saux, L. Jullien & A. Gautier

Expanding discriminative dimensions for analysis and imaging.
Chemical Science 6, 2968-2978 (2015). 
J. Querard, A. Gautier*, T. Le Saux* & L. Jullien*

Photoswitching kinetics and phase sensitive detection add discriminative dimensions for selective fluorescence imaging.
Angewandte Chemie International Edition 54, 2633-2637 (2015).
J. Querard, T.-Z. Markus, M.-A. Plamont, C. Gauron, P. Wang, A. Espagne, M. Volovitch, S. Vriz, V. Croquette, A. Gautier*, T. Le Saux* & L. Jullien*

Preface. Site-specific protein labeling
Site-Specific Protein Labeling: Methods and Protocols, Methods in Molecular Biology, Vol. 1266 (Gautier, A. & Hinner M. J., eds), pp v-viii, Humana Press, USA (2015).
A. Gautier & M. J. Hinner

Site-specific protein labeling, Methods and Protocols series (Book)
Methods in Molecular Biology, Vol. 1266, Humana Press, USA (2015).
A. Gautier & M. J. Hinner (Editors)


Fluorogen activating and shifting tag (FAST)
Patent Pub. No.: WO/2016/001437, International Application No.: PCT/EP2015/065267.
A. Gautier & L. Jullien

How to control proteins with light in living systems.
Nature Chemical Biology 10, 533-541 (2014). 
A. Gautier, C. Gauron, M. Volovitch, D. Bensimon, L. Jullien & S. Vriz

Nitric oxide-triggered remodeling of chloroplast bioenergetics and thylakoid proteins upon nitrogen starvation in Chlamydomonas reinhardtii.
Plant Cell 26, 353-372 (2014).
L. Wei, B. Derrien, A. Gautier, L. Houille-Vernes, A. Boulouis, D. Saint-Marcoux, A. Malnoe, F. Rappaport, C. de Vitry, O. Vallon, Y. Choquet & F.-A. Wollman


Method for the detection of reversibly photoswitchable fluorescent species .
Patent Pub. No.: WO/2015/075209, International Application No.: PCT/EP2014/075336.
V. Croquette, A. Gautier, L. Jullien, T. Le Saux, S. S. Nath, J. Querard, P. Wang

Photochemical properties of Spinach and its use in selective imaging.
Chemical Science 4, 2865-2873 (2013). 
P. Wang, J. Querard, S. Maurin, S. S. Nath, T. Le Saux*, A. Gautier* & L. Jullien*


Self-immolation for uncaging with fluorescence reporting.
Angewandte Chemie International Edition 57, 9344-9347 (2012). 
R. Labruère, A. Alouane, T. Le Saux, I. Aujard, P. Pelupessy, A. Gautier, S. Dubruille, F. Schmidt & L. Jullien

Modification-free photocontrol of β-lactam conversion with spatio-temporal resolution.
ACS Synthetic Biology 1, 526-531 (2012). 
A. Venancio-Marques, Y.-J. Liu, A. Diguet, T. di Maio, A. Gautier & D. Baigl


Genetically encoded photocontrol.
Patent Pub. No.: WO/2011/107747; International Application No.: PCT/GB2011/000304.
J. Chin, D.P. Nguyen, A. Gautier, A. Deiters

Light-activated kinases enable the temporal dissection of signaling networks in living cells.
 Journal of the American Chemical Society 133, 2124-2127 (2011). 
A. Gautier, A. Deiters & J.W. Chin


Genetically encoded photocontrol of protein localization in mammalian cells.
Journal of the American Chemical Society 132, 4086-4088 (2010). 
A. Gautier, D.P. Nguyen, H. Lusic, W. An, A. Deiters & J.W. Chin


Selective crosslinking of interacting proteins using self-labeling tags.
Journal of the American Chemical Society 131, 17954-17962 (2009). 
A. Gautier, E. Nakata, G. Lukinavičius, K.T. Tan & K. Johnsson

The N-C=O interaction: a weak bond with attractive properties for the deliberate exploitation in medicinal and supramolecular chemistry.
In Targets in heterocyclic systems – Chemistry and Properties, Volume 13 (Attanasi, O.A., Spinelli, D., eds.), pp. 1-26, The Royal Society of Chemistry (2009).
J. Hasserodt, A. Gautier, R. Barbe & M. Waibel


AGT/SNAP-tag: a versatile tag for covalent protein labeling.
In Probes and tags to study biomolecular function: for proteins, RNA and membranes (Miller, L.W., ed.), pp. 89-107, Wiley-VCH, Weinheim (2008).
A. Gautier, K. Johnsson & H.M. O’Hare

An engineered protein tag for multiprotein labeling in living cells.
Chemistry & Biology 15, 128-136 (2008). 
A. Gautier, A. Juillerat, C. Heinis, I.R. Correa, M. Kindermann, F. Beaufils & K. Johnsson


Labeling of fusion proteins with synthetic probes.
Patent Pub. No.: WO/2008/012296 ; International Application No.: PCT/EP2007/057597.
A. Gautier, K. Johnsson, M. Kindermann, A. Juillerat & F. Beaufils

Chemical probes shed light on protein function.
Current Opinion in Structural Biology 17, 488-494 (2007). 
H. M. O’Hare, K. Johnsson & A. Gautier

Observing and manipulating proteins in living cells – Covalent labeling of fusion proteins.
BIOforum Europe 11, 38-40 (2007).
K. Johnsson, H. O’Hare & A. Gautier


An unusual functional group interaction and its potential to reproduce steric and electrostatic features of the transition states of peptidolysis.
Bioorganic & Medicinal Chemistry 14, 3835-3847 (2006).
A. Gautier, D. Pitrat & J. Hasserodt


Chiral trialkanolamine-based hemicryptophanes: Synthesis and oxovanadium complex.
Organic Letters 7, 1207-1210 (2005). 
A. Gautier, J.-C. Mulatier, J. Crassous & J.-P Dutasta