Publications

2019

The glowing panoply of fluorogen-based markers for advanced bioimaging.
In Optogenetics: light-driven actuators and light-emitting sensors in cell biology, Comprehensive Series in Photochemical and Photobiological Sciences (S. Vriz & T. Ozawa Eds), pp 41-62, The Royal Society of Chemistry (2019).
A. Gautier

2018

Spying on cells with chemical-genetic hybrids (Espionner les cellules avec des hybrides chémogénétiques)
L’Actualité Chimique, soon to appear
A. Gautier

Macroscale fluorescence imaging against autofluorescence under ambient light
Light: Science & Applications (just accepted)
R. Zhang, R. Chouket, M.-A. Plamont, Z. Kelemen, A. Espagne, A. G. Tebo, A. Gautier, L. Gissot, J.-D. Faure, L. Jullien, V. Croquette & T. Le Saux

Improved chemical-genetic fluorescent markers for protein imaging in living cells.
Biochemistry 57, 5648–5653 (2018)
A. G. Tebo, F. M. Pimenta, Y. Zhang & A. Gautier

Fluorogenic protein-based strategies for detection, actuation and sensing.
BioEssays 40,1800118 (2018)
A. Gautier & A. G. Tebo

Circularly permuted fluorogenic proteins for the design of modular biosensors.
ACS Chemical Biology 13, 2392–2397 (2018)
A. G. Tebo, F. M. Pimenta, M. Zoumpoulaki, C. Kikuti, H. Sirkia, M.-A. Plamont, A. Houdusse & A. Gautier

The inducible chemical-genetic fluorescent marker FAST outperforms classical fluorescent proteins for the accurate quantitative monitoring of bacterial biofilm dynamics.
Scientific Reports 8, 10336 (2018) 
A. Monmeyran, P. Thomen, H. Jonquière, F. Sureau, C. Douarche, C. Li, M.-A. Plamont, J.-F. Casella, A. Gautier & N. Henry

Fluorogenic probing of membrane protein trafficking.
Bioconjugate Chemistry 29, 1823–1828 (2018)
C. Li, A. Mourton, M.-A. Plamont, V. Rodrigues, I. Aujard, M. Volovitch, T. Le Saux, F. Perez, S. Vriz, L. Jullien, A. Joliot & A. Gautier

2017

Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations.
Nature Communications 8, 969 (2017)
J. Querard, R. Zhang, Z. Kelemen, M.-A. Plamont, X. Xie, R. Chouket, I. Roemgens, Y. Koperina, S. Albright, E. Ipendey, M. Volovitch, H. L. Sladitschek, P. Neveu, L. Gissot, A. Gautier, J.-D. Faure, V. Croquette, T. Le Saux & L. Jullien

Chromophore renewal and fluorogen-binding tags: a match made to last.
Scientific Reports 7, 12316 (2017)
F. M. Pimenta, G. Chiappetta, T. Le Saux, J. Vihn, L. Jullien & A. Gautier

Fluorogenic labeling strategies for biological imaging.
International Journal of Molecular Sciences 18, 1473 (2017)
C. Li, A. G. Tebo & A. Gautier

Hybrid fluorescent probes for imaging cellular proteins on demand.
Médecine/Sciences 33 (6-7), 576-578 (2017)
L. Jullien & A. Gautier

Membrane-impermeant fluorogenic chromophores.
Patent Application number : EP17305591.4
A. Gautier, L. Jullien, C. Li, F. Perez

Dynamic multi-color protein labeling in living cells.
Chemical Science 8, 5598–5605 (2017) 
C. Li, M.-A. Plamont, H. Sladitschek, V. Rodrigues, I. Aujard, P. Neveu, T. Le Saux, L. Jullien & A. Gautier

PSL Chemical Biology Symposium First 2016 Edition: When Chemistry and Biology share the language of discovery.
ChemBioChem 18, 883-887 (2017)
A. Gautier & R. Rodriguez

2016

Design and characterization of red fluorogenic push-pull chromophores holding great potential for biosensing and imaging.
Organic and Biomolecular Chemistry 14, 9253-9261 (2016)
C. Li, M.-A. Plamont, I. Aujard, T. Le Saux, L. Jullien & A. Gautier

Kinetics of reactive modules adds discriminative dimensions for selective cell imaging.
ChemPhysChem 17, 1396-1413 (2016)
J. Quérard, T. Le Saux, A. Gautier, D. Alcor, V. Croquette, C. Gosse, A. Lemarchand & L. Jullien

A small fluorescence-activating and absorption-shifting tag for tunable protein imaging in vivo.
Proceedings of the National Academy of Sciences (PNAS) 113 (3), 497-502 (2016)   
M.-A. Plamont, E. Billon-Denis, S. Maurin, C. Gauron, F. M. Pimenta, C. G. Specht, J. Shi, J. Querard, B. Pan, J. Rossignol, K. Moncoq, N. Morellet, M. Volovitch, E. Lescop, Y. Chen, A. Triller, S. Vriz, T. Le Saux, L. Jullien & A. Gautier
Highlighted in ‘This week in PNAS’ in PNAS 113 (3), 465-467 (2016).

2015

Fluorogen-based reporters for fluorescence imaging: a review.
Methods and Applications in Fluorescence 3, 042007 (2015)
L. Jullien & A. Gautier

Light-activated proteolysis for the spatiotemporal control of proteins.
ACS Chemical Biology 10, 1643-1647 (2015) 
Q. Delacour, C. Li, M.-A. Plamont, E. Billon-Denis, I. Aujard, T. Le Saux, L. Jullien & A. Gautier

Expanding discriminative dimensions for analysis and imaging.
Chemical Science 6, 2968-2978 (2015) 
J. Querard, A. Gautier*, T. Le Saux* & L. Jullien*

Photoswitching kinetics and phase sensitive detection add discriminative dimensions for selective fluorescence imaging.
Angewandte Chemie International Edition 54, 2633-2637 (2015)
J. Querard, T.-Z. Markus, M.-A. Plamont, C. Gauron, P. Wang, A. Espagne, M. Volovitch, S. Vriz, V. Croquette, A. Gautier*, T. Le Saux* & L. Jullien*

Preface. Site-specific protein labeling
Site-Specific Protein Labeling: Methods and Protocols, Methods in Molecular Biology, Vol. 1266 (Gautier, A. & Hinner M. J., eds), pp v-viii, Humana Press, USA (2015)
A. Gautier & M. J. Hinner

Site-specific protein labeling, Methods and Protocols series (Book)
Methods in Molecular Biology, Vol. 1266, Humana Press, USA (2015)
A. Gautier & M. J. Hinner (Editors)

2014

Fluorogen activating and shifting tag (FAST)
Patent Pub. No.: WO/2016/001437, International Application No.: PCT/EP2015/065267
A. Gautier & L. Jullien

How to control proteins with light in living systems.
Nature Chemical Biology 10, 533-541 (2014) 
A. Gautier, C. Gauron, M. Volovitch, D. Bensimon, L. Jullien & S. Vriz

Nitric oxide-triggered remodeling of chloroplast bioenergetics and thylakoid proteins upon nitrogen starvation in Chlamydomonas reinhardtii.
Plant Cell 26, 353-372 (2014)
L. Wei, B. Derrien, A. Gautier, L. Houille-Vernes, A. Boulouis, D. Saint-Marcoux, A. Malnoe, F. Rappaport, C. de Vitry, O. Vallon, Y. Choquet & F.-A. Wollman

2013

Method for the detection of reversibly photoswitchable fluorescent species .
Patent Pub. No.: WO/2015/075209, International Application No.: PCT/EP2014/075336
V. Croquette, A. Gautier, L. Jullien, T. Le Saux, S. S. Nath, J. Querard, P. Wang

Photochemical properties of Spinach and its use in selective imaging.
Chemical Science 4, 2865-2873 (2013) 
P. Wang, J. Querard, S. Maurin, S. S. Nath, T. Le Saux*, A. Gautier* & L. Jullien*

2012

Self-immolation for uncaging with fluorescence reporting.
Angewandte Chemie International Edition 57, 9344-9347 (2012) 
R. Labruère, A. Alouane, T. Le Saux, I. Aujard, P. Pelupessy, A. Gautier, S. Dubruille, F. Schmidt & L. Jullien

Modification-free photocontrol of β-lactam conversion with spatio-temporal resolution.
ACS Synthetic Biology 1, 526-531 (2012) 
A. Venancio-Marques, Y.-J. Liu, A. Diguet, T. di Maio, A. Gautier & D. Baigl

2011

Genetically encoded photocontrol.
Patent Pub. No.: WO/2011/107747; International Application No.: PCT/GB2011/000304
J. Chin, D.P. Nguyen, A. Gautier, A. Deiters

Light-activated kinases enable the temporal dissection of signaling networks in living cells.
 Journal of the American Chemical Society 133, 2124-2127 (2011) 
A. Gautier, A. Deiters & J.W. Chin

2010

Genetically encoded photocontrol of protein localization in mammalian cells.
Journal of the American Chemical Society 132, 4086-4088 (2010) 
A. Gautier, D.P. Nguyen, H. Lusic, W. An, A. Deiters & J.W. Chin

2009

Selective crosslinking of interacting proteins using self-labeling tags.
Journal of the American Chemical Society 131, 17954-17962 (2009) 
A. Gautier, E. Nakata, G. Lukinavičius, K.T. Tan & K. Johnsson

The N-C=O interaction: a weak bond with attractive properties for the deliberate exploitation in medicinal and supramolecular chemistry.
In Targets in heterocyclic systems – Chemistry and Properties, Volume 13 (Attanasi, O.A., Spinelli, D., eds.), pp. 1-26, The Royal Society of Chemistry (2009)
J. Hasserodt, A. Gautier, R. Barbe & M. Waibel

2008

AGT/SNAP-tag: a versatile tag for covalent protein labeling.
In Probes and tags to study biomolecular function: for proteins, RNA and membranes (Miller, L.W., ed.), pp. 89-107, Wiley-VCH, Weinheim (2008)
A. Gautier, K. Johnsson & H.M. O’Hare

An engineered protein tag for multiprotein labeling in living cells.
Chemistry & Biology 15, 128-136 (2008) 
A. Gautier, A. Juillerat, C. Heinis, I.R. Correa, M. Kindermann, F. Beaufils & K. Johnsson

2007

Labeling of fusion proteins with synthetic probes.
Patent Pub. No.: WO/2008/012296 ; International Application No.: PCT/EP2007/057597
A. Gautier, K. Johnsson, M. Kindermann, A. Juillerat & F. Beaufils

Chemical probes shed light on protein function.
Current Opinion in Structural Biology 17, 488-494 (2007) 
H. M. O’Hare, K. Johnsson & A. Gautier

Observing and manipulating proteins in living cells – Covalent labeling of fusion proteins.
BIOforum Europe 11, 38-40 (2007)
K. Johnsson, H. O’Hare & A. Gautier

2006

An unusual functional group interaction and its potential to reproduce steric and electrostatic features of the transition states of peptidolysis.
Bioorganic & Medicinal Chemistry 14, 3835-3847 (2006)
A. Gautier, D. Pitrat & J. Hasserodt

2005

Chiral trialkanolamine-based hemicryptophanes: Synthesis and oxovanadium complex.
Organic Letters 7, 1207-1210 (2005) 
A. Gautier, J.-C. Mulatier, J. Crassous & J.-P Dutasta